UNICORNE

Uniprot-based Conformational Ensembles. Explore protein dynamics through normal modes, superposition, and hierarchical structural classification.

940,000+
Structures
54,000+
UniProts
25,000+
Fold classes
Explore database → Ensemble Generation Leaderboard Documentation
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Three ways to explore

Pick the angle that matches your question.

The same underlying database, surfaced three different ways — by sequence, by fold/domain, or by predictor performance.

UniProt view
54,000+
entries with multiple conformations

Search by UniProt ID, entry name, protein name, or PDB code. Each entry shows every aligned conformation with normal-mode animations and superposition overlays.

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Fold/Domain view
10,000+
ECOD folds · also CATH & InterPro splits

Navigate fold → domain → UniProt → conformations. Filter by total angle, sequence similarity, or member count to compare structural relationships across families.

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Ensemble Generation Leaderboard
829
benchmark ensembles · 7 prediction tools

UNICORNE_BENCH evaluates BioEMU, ESMFlow, AlphaFlow, ESMDiff, CFrandom, AFsample2, and SPEACH_AF against ground-truth ensembles with TMalign-based metrics.

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UNICORNE_BENCH is also integrated as a dataset in the proteinshakex package.

By the numbers

The largest aligned ensemble database in the field.

940,000+
Structures
Aligned across every UniProt entry with experimental coverage — monomers and oligomer assemblies.
54,000+
UniProt entries
Each with resolved conformational diversity — enough to study real motion.
25,000+
Fold classes across 3 splits
Browse the same ensembles under three independent classification systems:
10,000+ECOD folds
5,300+CATH folds
9,600+InterPro folds
Get started

Pick a protein. Watch it move.

No account, no install, no waiting. Open the database and start exploring.

Explore database → Ensemble Generation Leaderboard